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Improgan is a congener of the H 2 antagonist cimetidine, which produces potent antinociception. Because a) the mechanism of action of improgan remains unknown and b) this drug may indirectly activate cannabinoid CB 1 receptors, the effects of the CB 1 antagonist/inverse agonist rimonabant (SR141716A) and 3 congeners with varying CB 1 potencies were studied on improgan...
Improgan is a chemical congener of the H 2 antagonist cimetidine which shows the profile of a highly effective analgesic when administered directly into the CNS. Although the improgan receptor is unknown, improgan activates analgesic pathways which are independent of opioids, but may utilize cannabinoid mechanisms. To discover selective, potent, improgan-like drugs, seven compounds chemically...
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