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5-Hydroxymethylcytosine (5hmC), a novel modified cytosine, is oxidized from 5-methylcytosine (5mC) by the ten-eleven translocation (Tet) protein family. The specific distribution of 5hmC in mammalian brain and its roles in gene regulation suggest that 5hmC is important in brain development. 5hmC may also contribute to the mechanisms underlying neurological diseases. Here, we summarize the current...
Increasingly complex networks of noncoding RNAs are being found to play important and diverse roles in the regulation of gene expression throughout the genome. Many lines of evidence are linking mutations and dysregulations of noncoding RNAs to a host of human diseases, and noncoding RNAs have been implicated in the molecular pathogenesis of some neurodegenerative disorders. The expansion of trinucleotide...
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