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Stress response biologic systems are altered in alcohol‐dependent individuals. Early life stress (ELS) is associated with a heightened risk of alcohol dependence, presumably because of stress‐induced neuroplastic changes. This study was designed to assess the contribution of ELS to a stress‐induced neural response in alcohol‐dependent participants. Fifteen alcohol‐dependent men abstinent for 3–5 weeks...
To properly formulate functional magnetic resonance imaging (fMRI) experiments with complex mental activity, it is advantageous to permit great flexibility in the statistical components of the design of these studies. The length of an experiment, the placement of various stimuli and the modeling approach used all affect the ability to detect mental activity. Major advances in understanding the implications...
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