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To elucidate the effects of tumor necrosis factor (TNF)-α on the expression of inducible nitric oxide synthase (iNOS) in retinal pigment epithelial cells in vitro.ARPE-19 cell lines were cultured with TNF-α stimulation, and then treated with proteasome inhibitors (MG132 or lactacystin) for 30 minutes. The expression of iNOS was determined by RT-PCR and Western blot. The expression of nitric oxide...
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