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Pleiotrophin (PTN) and midkine (MK) form a distinct family of heparin binding growth factors. In a variety of human cancers, MK mRNA levels have been found to be increased as compared to adjacent non-cancerous tissues. We examined the expression of PTN, its putative receptor, namely protein tyrosine phosphataseζ (PTPζ, also known as RPTPβ), and a related protein, receptor-type protein tyrosine phosphataseγ...
Midkine (MK) is a growth differentiation factor originally found as the product of a retinoic acid-responsive gene. The expression of MK was examined in 35 surgically resected specimens of primary colorectal cancer using the reverse transcription-polymerase chain reaction (RT-PCR). All of the cancerous tissues expressed MK. In 525 cancerous tissues a truncated form of MK, which was recently found...
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