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In a previous study of ours, a new synthetic method for haptens of organophosphorus (OP) pesticides, with a spacer arm (aminocarboxylic acid) attached at the thiophosphate group, was developed and applied to the synthesis of haptens for the OP insecticide fenthion. Polyclonal antibodies were obtained from the haptens that were conjugated to carrier proteins. In this study, the effect of hapten heterology...
A simple synthetic method for haptens of organophosphorus (OP) pesticides with a spacer arm (aminocarboxylic acid) attached at the pesticide thiophosphate group was developed. While the previous synthetic approach for this type of haptens requires seven steps, the present method involves only two steps. Using this method, four haptens of the OP insecticide parathion-methyl were synthesized. Rabbits...
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