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The tumor suppressor gene ARF is formed by three exons, namely exons 1β, 2 and 3. Here, we show that embryo fibroblasts from mice genetically deficient in exons 2 and 3 (Δ2,3) express a transcript formed by exon 1β followed by the 3'-terminal exon of the gene immediately downstream of the INK4a/ARF locus, which we have called NTp16 (Next-To-p16). The chimeric ARF-NTp16 transcript is not detectable...
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