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Estrogen-related receptors (ERRs) are constitutively active orphan nuclear receptors. Natural ligands have not been identified, however, recent reports have demonstrated the synthetic phenolic acyl hydrazone, GSK4716, functions as a selective ERRβ/γ agonist. We demonstrate that ERRβ is transiently induced, and ERRγ is dramatically induced (and accumulates) in a differentiation-dependent manner in...
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