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Résumé La cathepsine S (CTSS) est une protéase à cystéine dont l’implication physiopathologique est établie dans l’athérosclérose et la présentation d’antigène. Par une approche transcriptomique, nous avons montré que la CTSS est exprimée dans le tissu adipeux humain et augmente avec la corpulence. Cette revue décrit les études menées par la suite montrant que la CTSS circulante varie avec les changements...
It is now recognized that the white adipose tissue (WAT) produces a variety of bioactive peptides, collectively termed “adipokines”. Alteration of WAT mass in obesity or lipoatrophy, affects the production of most adipose secreted factors. Since both conditions are associated with multiple metabolic disorders and increased risk of cardiovascular diseases, the idea has emerged that WAT could be instrumental...
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