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Epidemiological studies found an increased risk for kidney cancer in hypertensive patients, of which a subgroup has high aldosterone (Ald) levels. We recently showed that Ald is genotoxic both in kidney tubular cells and in rats with mineralocorticoid‐mediated hypertension. The present work investigated in vitro and in vivo, if the oxidative stress‐mediated activation of the ERK1/2 pathway, and its...
An increase of the mineralocorticoid aldosterone is induced by a stimulated renin–angiotensin system in a subgroup of hypertensive patients. Epidemiological studies find higher cancer mortality in hypertensive patients and an increased risk to develop kidney cancer. This work investigated the involvement of oxidants in the genotoxicity of aldosterone and on a potential activation of transcription...
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