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This open-label phase II trial assessed mitoxantrone/prednisone (M/P) with and without siltuximab (CNTO 328), an anti-interleukin-6 chimeric monoclonal antibody, for patients with metastatic castration-resistant prostate cancer who received prior docetaxel-based chemotherapy.Part 1 assessed the safety of biweekly siltuximab 6mg/kg plus M 12mg/m 2 every 3weeks and P. Part 2 assessed efficacy...
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