Search results for: K. Siraj

Items from 1 to 20 out of 47 results

article

Prevalence, spectrum, and founder effect of BRCA1 and BRCA2 mutations in epithelial ovarian cancer from the Middle East

Abdul K. Siraj, Rong Bu, Kaleem Iqbal, Nabil Siraj, more

Germline mutations in breast cancer susceptibility gene 1 and 2 have previously been estimated to contribute to 13–18% of all epithelial ovarian cancer (EOC). To characterize the prevalence and effect of BRCA1 and BRCA2 mutations in Middle Eastern EOC patients, BRCA mutation screening was performed in 407 unselected ovarian cancer patients using targeted capture and/or Sanger sequencing. A total of...

article

Effect of Au ion beam on structural, surface, optical and electrical properties of ZnO thin films prepared by RF sputtering

M. Fiaz Khan, K. Siraj, A. Sattar, S. Majeed, more

Ceramics International > 2018 > 44 > 14 > 16464- 16469

In the present work, ZnO thin films were irradiated with 700 keV Au⁺ ions at different fluence (1 × 10¹³, 1 × 10¹⁴, 2 × 10¹⁴ and 5 × 10¹⁴ ions/cm²). The structural, morphological, optical and electrical properties of pristine and irradiated ZnO thin films were characterized by X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FTIR), scanning electron microscope (SEM), spectroscopy...

article

Telomerase reverse transcriptase mutations are independent predictor of disease‐free survival in Middle Eastern papillary thyroid cancer

Rong Bu, Abdul K. Siraj, Sasidharan Padmaja Divya, Yan Kong, more

International Journal of Cancer > 142 > 10 > 2028 - 2039

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor recurrence occurs in ∼20% of PTCs and some reach advanced stages. Promoter mutation in the telomerase reverse transcriptase (TERT) gene is identified to be a prognostic marker in PTC. However, the contribution of TERT promoter mutation to cancer progression in PTC patients is still not fully understood. In this study,...

article

Influence of Er doping on the structural, optical and luminescence properties of pulsed laser deposited Er: BaZrO3 thin films

Shariqa Hassan Butt, M.S. Rafique, Shazia Bashir, Usman Ilyas, more

Ceramics International > 2017 > 43 > 15 > 12162- 12166

Pure and erbium doped (1, 2, 3 and 5at%) Barium zirconate (BZE) thin films have been deposited on Si (0 0 1) substrate via pulsed laser deposition using 100mJ Nd: YAG laser operated at second harmonics (532nm). Er doping significantly affects the surface morphology, microstructure and optical properties of grown thin films. All the films exhibit cubic BaZrO₃ structure and are polycrystalline in nature...

article

Expanding the spectrum of germline variants in cancer

Abdul K. Siraj, Tariq Masoodi, Rong Bu, Sandeep Kumar Parvathareddy, more

Human Genetics > 2017 > 136 > 11-12 > 1431-1444

Our ability to identify germline variants in hereditary cancer cases remains challenged by the incomplete cataloging of relevant genes and lack of consensus on who should be tested. We designed a panel [hereditary oncogenesis predisposition evaluation (HOPE)] that encompasses most of the genes known to be associated with cancer development and tested its yield on more than 1300 samples of cancer patients...

article

Response to Yehia et al.

Abdul K. Siraj, Tariq Masoodi, Fowzan S. Alkuraya, Khawla S. Al-Kuraya

The American Journal of Human Genetics > 2017 > 100 > 3 > 564-565

article

Electron beam fracturing of ZnO nanostructures and modification in optical band gap

K Siraj, M Kanwal, S Saleem, J D Pedarnig, more

Indian Journal of Physics > 2016 > 90 > 12 > 1431-1436

In our previous work Siraj et al (J Alloys Comp 563:280, 2013), the electron beam irradiation at high energies (6–15 MeV) at constant dose of 30 Gy produced Zinc oxide elongated nanostructures and modified the optical band gap energies accordingly. In present work, those nanostructures are fractured to smaller sizes by increasing the electron doses to 100 and 200 Gy. The very high temperature gradient...

article

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis

Rong Bu, Abdul K. Siraj, Khadija A.S. Al‐Obaisi, Shaham Beg, more

International Journal of Cancer > 139 > 5 > 1091 - 1097

Ethnic differences of breast cancer genomics have prompted us to investigate the spectra of BRCA1 and BRCA2 mutations in different populations. The prevalence and effect of BRCA 1 and BRCA 2 mutations in Middle Eastern population is not fully explored. To characterize the prevalence of BRCA mutations in Middle Eastern breast cancer patients, BRCA mutation screening was performed in 818 unselected...

article

Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis

Abdul K. Siraj, Tariq Masoodi, Rong Bu, Shaham Beg, more

The American Journal of Human Genetics > 2016 > 98 > 6 > 1170-1180

Papillary thyroid carcinoma (PTC) has a wide geographic variation in incidence; it is most common in Saudi Arabia, where it is only second to breast cancer as the most common cancer among females. Genomic profiling of PTC from Saudi Arabia has not been attempted previously. We performed whole-exome sequencing of 101 PTC samples and the corresponding genomic DNA to identify genes with recurrent somatic...

article

Reply to specific gene patterns and molecular pathways related to human carcinogenesis in different populations among various geographic locations

Abdul K. Siraj, Shaham Beg, Khawla S. Al‐Kuraya

Cancer > 122 > 7 > 1135 - 1137

article

700keV Ni+2 ions induced modification in structural, surface, magneto-optic and optical properties of ZnO thin films

M. Fiaz Khan, K. Siraj, M.S. Anwar, M. Irshad, more

Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions... > 2016 > 368 > C > 45-49

We investigate the effect of 700keV Ni⁺² ions irradiation at different ion fluences (1×10¹³, 1×10¹⁴, 2×10¹⁴, 5×10¹⁴ions/cm²) on the structural, surface, magneto-optic and optical properties of ZnO thin films. The X-ray diffraction (XRD) results show improved crystallinity when ion fluence is increased to 2×10¹⁴ions/cm², while deterioration is observed at the highest ion fluence of 5×10¹⁴ions/cm²....

article

Microstructural and optical properties of dysprosium doped copper oxide thin films fabricated by pulsed laser deposition technique

Hafsa Faiz, K. Siraj, M. F. Khan, M. Irshad, more

Journal of Materials Science: Materials in Electronics > 2016 > 27 > 8 > 8197-8205

Thin films of pure and dysprosium doped (1, 2, 3 and 5 at. wt%) copper oxide (Dy-CuO) are deposited onto p-silicon (1 0 0) substrate using pulsed laser deposition technique under vacuum at 300 °C. Dy doping concentration considerably influences the microstructure, surface morphology and optical properties of CuO thin films. All the films exhibit polycrystalline nature. The reduced crystallite size...

article

Epitaxial thin-film growth of Ruddlesden–Popper-type Ba₃Zr₂O₇ from a BaZrO₃ target by pulsed laser deposition

Shariqa Hassan Butt, M. S. Rafique, K. Siraj, A. Latif, more

Applied Physics A > 2016 > 122 > 7 > 1-9

Ruddlesden–Popper Ba₃Zr₂O₇ thin films have been synthesized via pulsed laser deposition (PLD) technique. The optimization of deposition parameters in PLD enables the formation of thin film of metastable Ba₃Zr₂O₇ phase from BaZrO₃ target. In order to see the post-annealing effects on the structural and optical properties, the deposited Ba₃Zr₂O₇ thin films were annealed at 500, 600 and 800 °C. X-ray...

article

Molecular markers and pathway analysis of colorectal carcinoma in the Middle East

Shaham Beg, Abdul K. Siraj, Sarita Prabhakaran, Rong Bu, more

Cancer > 121 > 21 > 3799 - 3808

BACKGROUNDColorectal cancer (CRC) is one of the most common cancers in the world. A newly proposed integrated pathway comprising traditional, alternate, and serrated pathways by genetic and epigenetic factors was defined recently and hypothesized to play a role in the pathogenesis of CRC; however, to the authors' knowledge, there is a paucity of information regarding these proposed molecular pathways...

article

ALK alteration is a frequent event in aggressive breast cancers

Abdul K. Siraj, Shaham Beg, Zeenath Jehan, Sarita Prabhakaran, more

Breast Cancer Research > 2015 > 17 > 1 > 1-12

Introduction Breast cancer is the most common female malignancy worldwide and, despite improvements in treatment modalities, there are increased chances of recurrence and metastasis in a substantial number of cases and it remains one of the major causes of mortality among female cancer patients. Anaplastic lymphoma kinase (ALK) gene has been found to be altered in several solid and hematologic tumors...

article

Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer

Abdul K. Siraj, Sarita Prabhakaran, Prashant Bavi, Rong Bu, more

Cancer > 121 > 11 > 1762 - 1771

BACKGROUNDLynch syndrome (LS; hereditary nonpolyposis colorectal cancer) is a common cause of hereditary colorectal cancer (CRC). CRC is the most common cancer diagnosed among males in Saudi Arabia but to the authors' knowledge there is a lack of data regarding the prevalence of LS in patients with CRC. There currently are no clear guidelines for the selection criteria for these patients to screen...

article

Effect of zinc induced compressive stresses on different properties of copper oxide thin films

H. Faiz, K. Siraj, M. S. Rafique, S. Naseem, more

Indian Journal of Physics > 2015 > 89 > 4 > 353-360

Thin films of pure and zinc doped copper oxide have been grown on Si (1 0 0) substrate using pulsed laser deposition at varying concentrations of zinc. The effects of the doping concentration on structural, surface and optical properties of all thin films have been investigated. X-ray diffraction shows the presence of monoclinic CuO phase and compressive stresses in all thin films. The Raman...

article

Microstructural and Optical Properties of Zinc Doped Copper Oxide Thin Films

K. Siraj, H. Faiz, M.S. Rafique, S. Naseem

Materials Today: Proceedings > 2015 > 2 > 10 Part B > 5426-5429

Thin films of pure and zinc doped copper oxide were prepared using pulsed laser deposition (PLD) technique. The effect of zinc concentration on microstructural and optical properties of thin films was analyzed. Microstructural analyses showed the presence of monoclinic CuO phase and compressive stresses. Micrographs showed smooth surface morphology free from micron-sized particles. The optical band...

article

Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells

Maqbool Ahmed, Azhar R Hussain, Abdul K. Siraj, Shahab Uddin, more

Molecular Cancer > 2015 > 14 > 1 > 1-14

Background Cross-talk between deregulated signaling pathways in cancer cells causes uncontrolled growth and proliferation. These cancers cells become more aggressive and quickly develop resistance to therapy. Therefore targeting of these deregulated pathways simultaneously can result in efficient cell death of cancer cells. In this study we investigated co-expression of Cox-2 and FoxM1 in a cohort...

article

Loss of PTEN expression is associated with aggressive behavior and poor prognosis in Middle Eastern triple-negative breast cancer

Shaham Beg, Abdul K. Siraj, Sarita Prabhakaran, Zeenath Jehan, more

Breast Cancer Research and Treatment > 2015 > 151 > 3 > 541-553

PTEN is a tumor suppressor that negatively regulates the PI3 K-AKT signaling pathway which is involved in the pathogenesis of many different tumor types and serves as a prognostic marker in breast cancer. However, the significance of the role of PTEN in Middle Eastern ethnic breast cancer has not been explored especially with the fact that breast cancer originating from this ethnic population tend...

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Search results for: K. Siraj

Prevalence, spectrum, and founder effect of BRCA1 and BRCA2 mutations in epithelial ovarian cancer from the Middle East

Effect of Au ion beam on structural, surface, optical and electrical properties of ZnO thin films prepared by RF sputtering

Telomerase reverse transcriptase mutations are independent predictor of disease‐free survival in Middle Eastern papillary thyroid cancer

Influence of Er doping on the structural, optical and luminescence properties of pulsed laser deposited Er: BaZrO3 thin films

Expanding the spectrum of germline variants in cancer

Response to Yehia et al.

Electron beam fracturing of ZnO nanostructures and modification in optical band gap

Identification of novel BRCA founder mutations in Middle Eastern breast cancer patients using capture and Sanger sequencing analysis

Genomic Profiling of Thyroid Cancer Reveals a Role for Thyroglobulin in Metastasis

Reply to specific gene patterns and molecular pathways related to human carcinogenesis in different populations among various geographic locations

700keV Ni+2 ions induced modification in structural, surface, magneto-optic and optical properties of ZnO thin films

Microstructural and optical properties of dysprosium doped copper oxide thin films fabricated by pulsed laser deposition technique

Epitaxial thin-film growth of Ruddlesden–Popper-type Ba₃Zr₂O₇ from a BaZrO₃ target by pulsed laser deposition

Molecular markers and pathway analysis of colorectal carcinoma in the Middle East

ALK alteration is a frequent event in aggressive breast cancers

Prevalence of Lynch syndrome in a Middle Eastern population with colorectal cancer

Effect of zinc induced compressive stresses on different properties of copper oxide thin films

Microstructural and Optical Properties of Zinc Doped Copper Oxide Thin Films

Co-targeting of Cyclooxygenase-2 and FoxM1 is a viable strategy in inducing anticancer effects in colorectal cancer cells

Loss of PTEN expression is associated with aggressive behavior and poor prognosis in Middle Eastern triple-negative breast cancer

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