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Purpose Present study aimed at exploring advantages/disadvantages of amino acid modified trimethylated chitosan in conquering multiple gene delivery obstacles and thus providing comprehensive understandings for improved transfection efficiency. Methods Arginine, cysteine, and histidine modified trimethyl chitosan were synthesized and employed to self-assemble with plasmid DNA (pDNA) to form nanocomplexes,...
Cellular and intracellular processing of DNA/polymer nanocomplexes was optimized by tailoring the composition of crosslinking agents for improving in vitro and in vivo transfection efficiency. Nanocomplexes composed of trimethyl chitosan-arginine conjugate (TMC-Arg), plasmid DNA (pDNA), and different proportions of sodium tripolyphosphate (TPP) and poly(γ-glutamic acid) (γ-PGA) were prepared. All...
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