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Nanoparticles of insulin/hydroxy-propyl-methylcellulose (HPMC)–poly-lactic-co-glycolic acid (PLGA) were successfully prepared by a modified supercritical CO 2 anti-solvent technique. The particle size, yield and insulin content were significantly influenced by the mass ratio of PLGA to HPMC and the mass ratio of insulin to the blend of PLGA–HMPC as well as by the operating pressure, temperature...
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