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ObjectivesTo evaluate the time‐course of functional recovery after cavernous nerve injury using glial cell line‐derived neurotrophic factor‐transduced Schwann cell‐seeded silicon tubes.
MethodsSections of the cavernous nerves were excised bilaterally (5 mm), followed by immediate bilateral surgical repair. A total of 20 study nerves per group were reconstructed by interposition of empty silicon tubes...
Schwann cell–seeded guidance tubes have been shown to promote cavernous nerve regeneration, and the local delivery of neurotrophic factors may additionally enhance nerve regenerative capacity. The present study evaluates whether the transplantation of GDNF-overexpressing Schwann cells may enhance regeneration of bilaterally transected erectile nerves in rats.Silicon tubes seeded with either GDNF-overexpressing...
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