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Macleaya cordata (Willd.) (Papaveraceae) is used as an active component in the natural feed additive Sangrovit ® . Sangrovit ® contains mixture of the intact aerial parts and the fraction of quaternary benzo[c]phenanthridine alkaloids from M. cordata (FQBA). In a 90-day pilot toxicity trial, Sangrovit ® and the FQBA were tested for safety. Male Wistar rats were fed for 90 days...
Two polar benzo[c]phenanthridine alkaloids, chelerythrine (CHE) and dihydrochelerythrine (DHCHE), were extracted at 35°C and 10MPa (15MPa for real samples) from real and spiked plasma samples with acceptable recoveries (95.1% and 81.0%, respectively) using near-critical CO 2 modified with aqueous (1:1, v/v) methanol. The alkaloids were quantified by a liquid chromatographic/electrospray mass...
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