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Intestinal transport of sulfanilic acid was examined by means of an in vitro everted sac technique in rats immunized with a bovine γ-globulin–sulfanilic acid conjugate. At a low concentration of sulfanilic acid, the intestinal transport of sulfanilic acid was decreased in rats immunized with bovine γ-globulin–sulfanilic acid conjugate. This phenomenon was dose dependent and antigen specific, since...
Controlled-release (CR) drug products dissolve more slowly than conventional-release products, reflecting their quality of sustaining a prolonged therapeutic effect. A frequent practice with scored tablets when only half the dosage is desired is to divide the tablet at the score mark and administer only half of the product. The dissolution characteristics of the divided tablets are unknown. It is...
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