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Objective
To investigate the efficacy and safety of belimumab, a human immunoglobulin monoclonal antibody against B lymphocyte stimulator, in a subset of patients with systemic lupus erythematosus (SLE) who were hypocomplementemic (C3 <90 mg/dl and/or C4 <10 mg/dl) and anti–double‐stranded DNA (anti‐dsDNA) positive (≥30 IU/ml) at baseline.
Methods
In this phase III, double‐blind, placebo‐controlled...
ObjectiveAn uncommon manifestation of hepatitis C virus (HCV) infection is systemic vasculitis associated with type II cryoglobulinemia (cryoglobulinemic vasculitis), a proliferative B cell disorder that transforms into B cell malignancy in 5–10% of patients. The monoclonal rheumatoid factors (mRF) that bear the WA cross‐idiotype (Xid) are responsible for most cases of cryoglobulinemic vasculitis...
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