Search results for: Kristina Norman

Items from 1 to 20 out of 35 results

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Effects of a Short‐Term Vegan Challenge in Older Adults on Metabolic and Inflammatory Parameters—A Randomized Controlled Crossover Study

Lary Döschner, Kora Schulze, Lea Göger, Anja Bosy‐Westphal, more

Molecular Nutrition & Food Research > 68 > 4 > n/a - n/a

Scope A long‐term vegan diet carries the risk of insufficient protein and micronutrient intake for older adults. However, even a short‐term (48 h) vegan diet exerts positive metabolic effects in younger adults. In this study, we investigate the feasibility and effects of a short‐term vegan challenge on metabolic and inflammatory markers in older adults. Method and results In this randomized controlled...

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Vitamin D insufficiency is associated with metabolic syndrome independent of insulin resistance and obesity in young adults ‐ The Berlin Aging Study II

Nikolaus Buchmann, Nils Eckstein, Dominik Spira, Ilja Demuth, more

Diabetes/Metabolism Research and Reviews > 37 > 8 > n/a - n/a

Purpose Age‐related changes affect vitamin D absorption and metabolism. Low 25‐hydroxyvitamin D concentrations have been reported as risk factor for the development of metabolic syndrome (MetS). However, recent evaluations suggest this association might be explained by obesity or insulin resistance (IR) in subjects with MetS. Our aim was to analyze associations between vitamin D insufficiency and...

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Altered Adiponectin Response in Older Women Following Dextrose and High‐Fat Dietary Challenges

Catrin Herpich, Bastian Kochlik, Ulrike Haß, Daniela Weber, more

Molecular Nutrition & Food Research > 65 > 17 > n/a - n/a

Scope Despite its beneficial properties, higher adiponectin concentrations are paradoxically associated with mortality in advanced age. Several mechanisms are being discussed. However, little is known about postprandial regulation of adiponectin in older adults. We assessed age‐specific differences of the adiponectin response to different test meals considering potential determinants. Methods and...

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Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Amand F. Schmidt, Michael V. Holmes, David Preiss, Daniel I. Swerdlow, more

BMC Cardiovascular Disorders > 2019 > 19 > 1 > 1-10

Background We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. Methods Published and individual participant level data (300,000+ participants) were combined to construct a weighted PCSK9 gene-centric score (GS). Seventeen randomized placebo controlled PCSK9 inhibitor trials were included,...

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Sarkopene Adipositas und Inflammation

Kristina Norman, Christian Herder

Der Diabetologe > 2019 > 15 > 4 > 311-317

Hintergrund Die Kombination aus Übergewicht/Adipositas und reduzierter Skelettmuskelmasse (Sarkopenie) führt zu einem prognostisch ungünstigen Phänotyp, der als sarkopene Adipositas bezeichnet wird. Ziel der Arbeit Ziel dieser Arbeit ist, eine Übersicht über Diagnosekriterien der sarkopenen Adipositas, ihre klinischen Implikationen, die pathophysiologischen Ursachen mit besonderem Fokus auf der...

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Tri-country translation, cultural adaptation, and validity confirmation of the Scored Patient-Generated Subjective Global Assessment

Nicole Erickson, Lena J. Storck, Alexandra Kolm, Kristina Norman, more

Supportive Care in Cancer > 2019 > 27 > 9 > 3499-3507

Purpose The Scored Patient-Generated Subjective Global Assessment (PG-SGA) is the only malnutrition (risk) assessment tool that combines patient-generated measures with professional-generated (medical) factors. We aimed to apply international standards to produce a high quality, validated, translation and cultural adaptation of the original PG-SGA for the Austrian, German, and Swiss setting. Methods...

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ESPEN guidelines on nutritional support for polymorbid internal medicine patients

Filomena Gomes, Philipp Schuetz, Lisa Bounoure, Peter Austin, more

Clinical Nutrition > 2018 > 37 > 1 > 336-353

Polymorbidity (also known as multimorbidity) – defined as the co-occurrence of at least two chronic health conditions – is highly prevalent, particularly in the hospitalized population. Nonetheless, clinical guidelines largely address individual diseases and rarely account for polymorbidity. The aim of this project was to develop guidelines on nutritional support for polymorbid patients hospitalized...

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Feeling older, walking slower—but only if someone’s watching. Subjective age is associated with walking speed in the laboratory, but not in real life

Nanna Notthoff, Johanna Drewelies, Paulina Kazanecka, Elisabeth Steinhagen-Thiessen, more

European Journal of Ageing > 2018 > 15 > 4 > 425-433

The huge inter-individual differences in how people age have prompted researchers to examine whether people’s own perception of how old they are—their subjective age—could be a better predictor of relevant outcomes than their actual chronological age. Indeed, how old people feel does predict mortality hazards, and health-related measures such as walking speed may account for this association. In the...

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Food for thought: association between dietary tyrosine and cognitive performance in younger and older adults

Simone Kühn, Sandra Düzel, Lorenza Colzato, Kristina Norman, more

Psychological Research > 2019 > 83 > 6 > 1097-1106

The fact that tyrosine increases dopamine availability that, in turn, may enhance cognitive performance has led to numerous studies on healthy young participants taking tyrosine as a food supplement. As a result of this dietary intervention, participants show performance increases in working memory and executive functions. However, the potential association between habitual dietary tyrosine intake...

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Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin

Nikolaus Buchmann, Markus Scholz, Christina M. Lill, Ralph Burkhardt, more

Acta Diabetologica > 2017 > 54 > 11 > 1031-1038

Aims Inverse relationships have been described between the largely genetically determined levels of serum/plasma lipoprotein(a) [Lp(a)], type 2 diabetes (T2D) and fasting insulin. Here, we aimed to evaluate the nature of these relationships with respect to causality. Methods We tested whether we could replicate the recent negative findings on causality between Lp(a) and T2D by employing the Mendelian...

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Detection and treatment of medical inpatients with or at-risk of malnutrition: Suggested procedures based on validated guidelines

Lisa Bounoure, Filomena Gomes, Zeno Stanga, Ulrich Keller, more

Nutrition > 2016 > 32 > 7-8 > 790-798

Despite the high prevalence of malnutrition in the general inpatient population, there is a lack of knowledge in regard to detecting disease-related malnutrition and implementing nutritional support. Our aim was to suggest practical procedures for screening and treating malnourished or at-risk patients hospitalized in medical wards, thereby fostering a straightforward implementation of nutritional...

article

Lungenfunktion bei älteren Probanden mit metabolischem Syndrom und Typ-2-Diabetes

Nikolaus Buchmann, Kristina Norman, Elisabeth Steinhagen-Thiessen, Ilja Demuth, more

Zeitschrift für Gerontologie und Geriatrie > 2016 > 49 > 5 > 405-415

Hintergrund Vorangegangene Studien weisen auf einen Zusammenhang zwischen Typ-2-Diabetes (T2D), metabolischem Syndrom (MetS) und Lungenfunktion hin. Bislang bleibt unklar, welcher Pathomechanismus hierfür verantwortlich ist. Ziel der aktuellen Untersuchung im Rahmen der Berliner Altersstudie II (BASE-II) war es, den Einfluss von Muskel- und abdomineller Fettmasse auf die Lungenfunktion bei Probanden...

article

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

David Goldeck, Graham Pawelec, Kristina Norman, Elisabeth Steinhagen-Thiessen, more

Biogerontology > 2016 > 17 > 1 > 189-198

Hand-grip strength is strongly correlated with measures of muscle mass and can be taken to predict morbidity and mortality. The aim of this study was to investigate the relationship between hand-grip strength and other markers associated with immune ageing, such as Cytomegalovirus (CMV) infection, leukocyte telomere length and serum levels of inflammatory and anti-inflammatory markers in the elderly...

article

The Bioimpedance Phase Angle Predicts Low Muscle Strength, Impaired Quality of Life, and Increased Mortality in Old Patients With Cancer

Kristina Norman, Rainer Wirth, Maxi Neubauer, Rahel Eckardt, more

Journal of the American Medical Directors Association > 2015 > 16 > 2 > 173.e17-173.e22

We investigated the impact of low phase angle (PhA) values on muscle strength, quality of life, symptom severity, and 1-year mortality in older cancer patients.Prospective study with 1-year follow-up.Cancer patients aged >60 years.PhA was derived from whole body impedance analysis. The fifth percentile of age-, sex-, and body mass index-stratified reference values were used as cut-off. Quality...

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Bioelectrical phase angle and impedance vector analysis – Clinical relevance and applicability of impedance parameters

Kristina Norman, Nicole Stobäus, Matthias Pirlich, Anja Bosy-Westphal

Clinical Nutrition > 2012 > 31 > 6 > 854-861

The use of phase angle (PhA) and raw parameters of bioelectrical impedance analysis (BIA) has gained attention as alternative to conventional error-prone calculation of body composition in disease. This review investigates the clinical relevance and applicability of PhA and Bioelectrical Impedance Vector Analysis (BIVA) which uses the plot of resistance and reactance normalized per height.A comprehensive...

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TISSUE CELL INTEGRITY IS AN IMPORTANT DETERMINANT TO PREDICT MUSCLE STRENGTH IN PATIENT IN POST STROKE REHABILITATION

Michael Knops, Nicole Ebner, Nadja Scherbakov, Kristina Norman, more

Kidney Research and Clinical Practice > 2012 > 31 > 2 > A47

Physical disability is a common result and a major complication after stroke. The skeletal muscle is the main effector organ accountable for this disability. Yet, metabolic, structural and functional impairment of muscle tissue are not recognized as potential targets to improve post-stroke rehabilitation and remobilisation. We aimed to investigate metabolic and structural characteristics of the lean...

article

Effect of sexual dimorphism on muscle strength in cachexia

Kristina Norman, Nicole Stobäus, Judith Reiß, Jörg Schulzke, more

Journal of Cachexia, Sarcopenia and Muscle > 2012 > 3 > 2 > 111-116

Background Reduced muscle strength is a cardinal feature in cachexia. We investigated whether weight loss is associated differently with muscle strength in men and women in a large cohort of hospitalized patients. Methods One thousand five hundred hospitalized patients (whereof 718 men, mean age 57.6 ± 16.0 years, mean body mass index (BMI) 24.6 ± 4.8 kg/m²) were included in the study. Non-edematous...

article

Hand grip strength: Outcome predictor and marker of nutritional status

Kristina Norman, Nicole Stobäus, M. Cristina Gonzalez, Jörg-Dieter Schulzke, more

Clinical Nutrition > 2011 > 30 > 2 > 135-142

Among all muscle function tests, measurement of hand grip strength has gained attention as a simple, non-invasive marker of muscle strength of upper extremities, well suitable for clinical use. This review outlines the prognostic relevance of grip strength in various clinical and epidemiologic settings and investigates its suitability as marker of nutritional status in cross-sectional as well as intervention...

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Determinants of hand grip strength, knee extension strength and functional status in cancer patients

Kristina Norman, Nicole Stobäus, Christine Smoliner, Daniela Zocher, more

Clinical Nutrition > 2010 > 29 > 5 > 586-591

Decreased functionality and muscle weakness are prominent features in cancer patients. We investigated determinants of muscle function assessed by hand grip and knee extension strength as well as functional status in cancer patients.189 consecutively admitted cancer patients (age 60.8 ± 12.7 years, 96 male) were recruited. Muscle function was assessed by hand grip and knee extension strength, and...

article

Association between intestinal tight junction permeability and whole-body electrical resistance in healthy individuals: A hypothesis

Luzia Valentini, Jonathan Eggers, Johann Ockenga, Verena K. Haas, more

Nutrition > 2009 > 25 > 6 > 706-714

Intestinal permeability describes non-carrier–mediated modes of transport through the intestinal epithelium. Wrist–ankle bioimpedance analysis (BIA) is a standard method to determine body composition based on the measurements of whole-body electrical resistance and reactance values. The present report deals with the coincidentally observed associations between permeability results and electrical raw...

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INFONA - science communication portal

Search results for: Kristina Norman

Effects of a Short‐Term Vegan Challenge in Older Adults on Metabolic and Inflammatory Parameters—A Randomized Controlled Crossover Study

Vitamin D insufficiency is associated with metabolic syndrome independent of insulin resistance and obesity in young adults ‐ The Berlin Aging Study II

Altered Adiponectin Response in Older Women Following Dextrose and High‐Fat Dietary Challenges

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9

Sarkopene Adipositas und Inflammation

Tri-country translation, cultural adaptation, and validity confirmation of the Scored Patient-Generated Subjective Global Assessment

ESPEN guidelines on nutritional support for polymorbid internal medicine patients

Feeling older, walking slower—but only if someone’s watching. Subjective age is associated with walking speed in the laboratory, but not in real life

Food for thought: association between dietary tyrosine and cognitive performance in younger and older adults

Association between lipoprotein(a) level and type 2 diabetes: no evidence for a causal role of lipoprotein(a) and insulin

Detection and treatment of medical inpatients with or at-risk of malnutrition: Suggested procedures based on validated guidelines

Lungenfunktion bei älteren Probanden mit metabolischem Syndrom und Typ-2-Diabetes

No strong correlations between serum cytokine levels, CMV serostatus and hand-grip strength in older subjects in the Berlin BASE-II cohort

The Bioimpedance Phase Angle Predicts Low Muscle Strength, Impaired Quality of Life, and Increased Mortality in Old Patients With Cancer

Bioelectrical phase angle and impedance vector analysis – Clinical relevance and applicability of impedance parameters

TISSUE CELL INTEGRITY IS AN IMPORTANT DETERMINANT TO PREDICT MUSCLE STRENGTH IN PATIENT IN POST STROKE REHABILITATION

Effect of sexual dimorphism on muscle strength in cachexia

Hand grip strength: Outcome predictor and marker of nutritional status

Determinants of hand grip strength, knee extension strength and functional status in cancer patients

Association between intestinal tight junction permeability and whole-body electrical resistance in healthy individuals: A hypothesis

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