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Monoclonal gammopathy is characterized by the proliferation of a single clone of plasma cells that produces a homogeneous monoclonal protein (M protein). Each M protein consists of two heavy polypeptide chains of the same class and subclass and two light polypeptide chains of the same type. The heavy polypeptide chains are γin immunoglobulin (Ig) G, a in IgA, α in IgM, δ in IgD, and ε in IgE. The...
Multiple myeloma (MM) is a neoplastic disorder characterized by the proliferation of a single clone of plasma cells derived from B cells in the bone marrow. Frequently, the myeloma invades adjacent bone, destroying skeletal structures and resulting in bone pain and fractures. Occasionally, plasma cells infiltrate multiple organs and produce other symptoms. The excessive production of a monoclonal...
Multiple myeloma (MM) is a relatively common hematologic neoplasia with an annual incidence in the United States of approx 13,000 newly diagnosed patients and responsible for 1% of all cancer deaths. Some patients are diagnosed by chance and should not be treated unless there is evidence of an imminent complication or demonstration of progressive disease. However, most patients present with a variety...
Multiple Myeloma has been recognized since Ancient Times. The first well-documented case was reported in 1844 by Samuel Solly. The most commonly recognized case is that of Thomas Alexander McBean, a highly respectable tradesman from London in 1850. Mr. McBean excreted a large amount of protein that was described by Henry Bence Jones in the middle of the 19th century. Jones was a well-known physician...
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