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The purpose of this study was to determine whether the brain uptake of [18F]FPEB is influenced by P‐glycoprotein (P‐gp) and breast cancer resistance protein (Bcrp) as efflux transporters in rodents. To assess this possible modulation, positron emission tomography studies were performed in animal models of pharmacological or genetic ablation of these transporters. Compared with the control conditions,...
The aim of this study is to compare [ 18 F]FPEB and [ 18 F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BP ND ) values were calculated from the non-invasive Logan’s graphical analysis method. Although both radioligands showed similar...
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