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Increased colorectal epithelial cell proliferation is an early, common event in colorectal carcinogenesis. We conducted a pilot, colonoscopy‐based case‐control study (n = 49 cases, 154 controls) of incident, sporadic colorectal adenoma to investigate endogenous cell growth factors and receptor, as well as the balance of growth factors, as potential modifiable pre‐neoplastic biomarkers of risk for...
Transforming growth factor alpha (TGFα) and TGFβ1 are growth‐promoting and ‐inhibiting autocrine/paracrine growth factors, respectively, that may (1) affect risk for colorectal cancer and (2) be modifiable by anti‐proliferative exposures. The effects of supplemental calcium and vitamin D3 on these two markers in the normal‐appearing colorectal mucosa in humans are unknown. We conducted a pilot, randomized,...
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