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A current need exists for new potent and selective inhibitors of human hepatitis B virus (HBV). BMS-200475, a novel carbocyclic analog of 2 -deoxyguanosine, is a potent inhibitor of HBV (ED 50 =3nM) with relatively low cytotoxicity (CC 50 =30μM) as assayed in HepG2.2.15 cells. BMS-200475 also has selective activity against HBV compared to other viruses (in vitro ED ...
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