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Glutamatergic neurotransmission in the substantia nigra pars compacta and pars reticulata is mediated through N-methyl-d-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxaline propionic acid/kainate (AMPA) type receptors as well as other glutamate receptors and is critical for basal ganglia functioning. A major glutamatergic input to the substantia nigra originates in the subthalamic nucleus, and the...
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