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p21 WAF1/CIP1 is expressed in a majority of myeloma cells. To investigate the role of p21 in myeloma cell death, comparative studies using two clones of myeloma cells, Fas-sensitive RPMI8226, and Fas-resistant U266 were performed. These latter cells were also resistant to H 2 O 2 up to 100 μM, whereas the former cells were not. SAPK/JNK...
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