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A selective and simple reversed phase HPLC method using naphthalethyl stationary phase was developed and validated for the quantitative determination of Palonosetron hydrochloride (PALO), its related compounds and degradation products. Chromatographic separation (R s >2) was achieved with linear gradient mode of elution at a flow rate of 1mL/min and with UV detection at 210nm. The intra...
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