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Despite over 80 yr of clinical experience with high-fat ketogenic diets (KDs) in the treatment of refractory seizures, we do not understand their anticonvulsant mechanism. In addition, it is difficult to monitor the efficacy of the diet and predict seizure outcome. Patients usually follow the diet for up to 3 mo before deciding whether to continue with it (1). Like many aspects of the KD, this 3-mo...
We summarize here the evidence indicating that carbon from α-linolenate and linoleate is readily recycled into newly synthesized lipids. This pathway consumes the majority of these fatty acids that is not β-oxidized as a fuel. Docosahexaenoate undergoes less β-oxidation and carbon recycling than do α-linolenate or linoleate, but is it still actively metabolized by this pathway? Among polyunsaturates,...
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