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In article number 1700339, Yuan Ping, Guping Tang, and co‐workers develop a size‐switchable micellar system that can simultaneously target the nucleus and dilate the nucleopore to enhance the intranuclear delivery efficiency of anticancer drugs. This research defines a strategy for the improvement of intranuclear drug delivery capacity, which is expected to augment the overall therapeutic efficacy...
Although previous efforts have focused on altering the size of drug delivery carriers with the goal of improving the efficacy of anticancer therapy, the penetration of nuclear pores still represents a formidable barrier for the existing drug delivery systems. To this end, a cooperative, dimensional strategy is employed that can considerably improve intranuclear drug delivery to augment the overall...
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