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The mechanism of Na + -dependent transport of l-carnitine via the carnitine/organic cation transporter OCTN2 and the subcellular localization of OCTN2 in kidney were studied. Using plasma membrane vesicles prepared from HEK293 cells that were stably transfected with human OCTN2, transport of l-carnitine via human OCTN2 was characterized. Uptake of l-[ 3 H]carnitine by the OCTN2-expressing...
Purpose. To prove the functional significance of monocarboxylic acidtransporter, MCT1 at the blood-brain barrier (BBB) for the passage ofboth endogenous and exogenous monocarboxylic acids into the centralnervous system. Methods. Monocarboxylic acid transport at the BBB was studied inrats by using a newly established immortalized brain capillaryendothelial cell (BCEC) line, RBEC1, and the results...
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