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Memory is lost by the increased influx of extracellular Zn2+ into neurons. It is possible that intracellular Zn2+ dynamics is modified even at non-zincergic medial perforant pathway-dentate granule cell synapses along with aging and that vulnerability to the modification is linked to age-related cognitive decline. To examine these possibilities, vulnerability of long-term potentiation (LTP) maintenance,...
The idea that maintained LTP and memory are lost by either increase in intracellular Zn2+ in dentate granule cells or increase in intracellular Ca2+ was examined to clarify significance of the increases induced by excess synapse excitation. Both maintained LTP and space memory were impaired by injection of high K+ into the dentate gyrus, but rescued by co-injection of CaEDTA, which blocked high K+...
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