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Purpose
To assess the feasibility of CEST‐based creatine (Cr) mapping in brain at 3T using the guanidino (Guan) proton resonance.
Methods
Wild type and knockout mice with guanidinoacetate N‐methyltransferase deficiency and low Cr and phosphocreatine (PCr) concentrations in the brain were used to assign the Cr and protein‐based arginine contributions to the GuanCEST signal at 2.0 ppm. To quantify...
Purpose
To estimate the exchange rate of creatine (Cr) CEST and to evaluate the pH sensitivity of guanidinium (Guan) CEST in the mouse brain.
Methods
Polynomial and Lorentzian line‐shape fitting (PLOF) were implemented to extract the amine, amide, and Guan CEST signals from the brain Z‐spectrum at 11.7T. Wild‐type (WT) and knockout mice with the guanidinoacetate N‐methyltransferase deficiency (GAMT...
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