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BACKGROUND
Cancer‐related sexual dysfunction has been reported among adolescents and young adults (AYAs); however, its prevalence over time has not been examined. This longitudinal study investigated sexual dysfunction in AYAs over the course of 2 years after the initial diagnosis.
METHODS
Young adult patients (18‐39 years old) completed the Medical Outcomes Study Sexual Functioning Scale within...
BACKGROUND
Conservative management of aggressive prostate cancer in the elderly without definitive therapy has been associated with a 10‐year prostate cancer‐specific mortality of approximately 50%. The authors examined the prevalence of definitive therapy in elderly patients with intermediate‐risk or high‐risk disease.
METHODS
411,343 patients who were diagnosed from 2004 through 2012 with intermediate‐risk...
BACKGROUND
Outcomes for children with acute myeloid leukemia (AML) have improved over the past 20 years even though the medications used for induction therapy have not changed.
METHODS
This study analyzed data from patients with AML who were enrolled in successive protocols (AML97 and AML02) to determine the contributors to the improved outcomes of the latter clinical trial.
RESULTS
There were...
BACKGROUND
The objective of the current study was to examine social functioning among adolescents and young adults (AYAs) within the first 2 years after a cancer diagnosis and compare their scores with population norms and identify trajectories of social functioning over time and its correlates.
METHODS
A multicenter, longitudinal study was conducted among 215 AYA patients with cancer aged 14 to...
Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin‐based chemotherapy...
BACKGROUND
Prostate cancer (PCa) outcomes are impacted by socioeconomic and biologic factors. Ethnicity plays a role in the former, but little is known about the responsiveness of metastatic PCa to androgen‐deprivation therapy (ADT) among races.
METHODS
The Surveillance, Epidemiology, and End Results (SEER) registry was used to identify men who were diagnosed with distant, de novo, metastatic PCa...
BACKGROUND
The outcomes of patients with unresected anaplastic thyroid carcinoma (ATC) from the National Cancer Data Base (NCDB) were assessed, and potential correlations were explored between radiation therapy (RT) dose and overall survival (OS).
METHODS
The study cohort was comprised of patients who underwent either no surgery or grossly incomplete resection. Correlates of OS were explored using...
BACKGROUND
Most major cancer organizations seek to reduce sociodemographic disparities in high‐risk cancers partly by increasing access to theoretically high‐quality, academic‐oriented cancer care. The objective of this study was to determine whether academic centers have less sociodemographic treatment disparities than community centers using high‐risk prostate cancer as a test case.
METHODS
The...
BACKGROUNDPeople aged 26 to 34 years represent the greatest proportion of the uninsured, and they have the highest incidence of testicular cancers. The aim of this study was to investigate the association between insurance status and cancer outcomes in men diagnosed with germ cell tumors.
METHODSThe Surveillance, Epidemiology, and End Results database was used to identify 10,211 men diagnosed with...
BACKGROUNDTo the authors' knowledge, there are currently no standardized measures of tobacco use and secondhand smoke exposure in patients diagnosed with cancer, and this gap hinders the conduct of studies examining the impact of tobacco on cancer treatment outcomes. The objective of the current study was to evaluate and refine questionnaire items proposed by an expert task force to assess tobacco...
BACKGROUNDIn the current study, the authors sought to both characterize the national trends in proton therapy use for prostate cancer and determine the factors associated with receipt of this limited resource, using what to the best of their knowledge is the largest nationwide cancer registry.
METHODSThe National Cancer Data Base was used to identify 187,730 patients diagnosed with nonmetastatic...
Each year, 70,000 adolescents and young adults (AYAs) between ages 15 and 39 years in the United States are diagnosed with cancer. In 2006, a National Cancer Institute (NCI) Progress Review Group (PRG) examined the state of science associated with cancer among AYAs. To assess the impact of the PRG and examine the current state of AYA oncology research, the NCI, with support from the LIVESTRONG Foundation,...
Adolescent and young adult (AYA) patients with cancer have not attained the same improvements in overall survival as either younger children or older adults. One possible reason for this disparity may be that the AYA cancers exhibit unique biologic characteristics, resulting in differences in clinical and treatment resistance behaviors. This report from the biologic component of the jointly sponsored...
BACKGROUNDThe objective of this study was to determine whether a very low presenting prostate‐specific antigen (PSA) level was associated with greater prostate cancer–specific mortality (PCSM) among men with a Gleason score (GS) of 8 to 10.
METHODSThe Surveillance, Epidemiology, and End Results program was used to identify 328,904 men diagnosed with clinicalT1 (cT1)‐4N0M0 prostate cancer between...
BACKGROUNDThe optimal treatment for resected pancreatic cancer is controversial because direct comparisons of adjuvant chemotherapy (CT) alone and chemotherapy and radiotherapy (CRT) are limited. This study assessed outcomes of CT versus CRT in a national cohort to provide a modern estimate of comparative effectiveness.
METHODSPatients with pT1‐3N0‐1M0 pancreatic adenocarcinoma after pancreatectomy...
BACKGROUND
Elderly patients with early‐stage breast cancer (ESBC) derive a local control benefit from radiotherapy (RT) after lumpectomy, without any apparent effect on overall survival. Therefore, the use of RT is controversial. In the current study, the authors characterized updated trends in RT for elderly patients with estrogen receptor (ER)‐positive ESBC.
METHODS
Patients aged ≥70 years with...
BACKGROUNDThe objective of this study was to examine the effects of marital status on stage at presentation, receipt of treatment, and survival in patients with head and neck cancer (HNC).
METHODSThe Surveillance, Epidemiology, and End Results database was used to analyze 51,272 patients who were diagnosed with HNC from 2007 to 2010. The impact of marital status on cancer stage at presentation, receipt...
BACKGROUNDThe treatment of head and neck cancer (HNC) may cause substantial local and systemic symptomatic morbidities, but many patients have high symptom levels before treatment begins. Knowledge of disease‐related (treatment‐naive) symptom status would aid in the evaluation of the symptomatic benefit or burden of HNC therapies.
METHODSThe authors retrospectively examined symptoms, quality of life,...
BACKGROUNDBrentuximab vedotin (BV) is an anti‐CD30 monoclonal antibody‐drug conjugate that was approved in 2011 for the treatment of patients with anaplastic large cell and Hodgkin lymphomas. The product label indicates that 3 patients who were treated with BV developed progressive multifocal leukoencephalopathy (PML), a frequently fatal JC virus‐induced central nervous system infection. Prior immunosuppressive...
BACKGROUNDA prospective longitudinal study to profile patient‐reported symptoms during radiotherapy (RT) or concurrent chemoradiotherapy (CCRT) for head and neck cancer was performed. The goals were to understand the onset and trajectory of specific symptoms and their severity, identify clusters, and facilitate symptom interventions and clinical trial design.
METHODSParticipants in this questionnaire‐based...
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