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Inheritance of the apolipoprotein E (APOE) ε4 allele is associated with an increased risk of Alzheimer’s disease (AD). However, the risk of AD in APOE ε3/ε4 heterozygotes is variable. We tested the hypothesis that the risk of AD in APOE ε3/ε4 heterozygotes was linked to the relative levels of expression of apoE4 versus apoE3 protein. We measured the apoE4 isoform and total apoE using two specific...
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