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Development of Alzheimer's disease (AD) has been linked to the de‐regulation of estrogen and gonadotropins such as luteinizing hormone (LH). In this study, we found increases in AD pathology in the hippocampi of aged female 3xTg AD mice after ovariectomy that were unable to be reduced by estrogen therapy or down‐regulation of serum LH levels. Despite the lack of effect of these treatments on AD pathology,...
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