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There is extensive research regarding the neural mechanisms involved in satiety and meal termination; in contrast, there is very limited understanding of how meal onset is regulated. On the basis of several converging lines of evidence, we hypothesized that hippocampal neurons form a memory of a meal and inhibit meal onset during the postprandial period. As a first step, we tested whether reversible...
To investigate the hypothesis that central dopamine mediates the rewarding effect of orosensory stimulation by sucrose that increases eating, specific dopamine antagonists were administered prior to sham-feeding tests in which rats ingested various concentrations of sucrose. Sham feeding (SF) was used to preserve the orosensory stimulation of sucrose while it eliminated sucrose's postingestive effects...
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