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To optimize a receptor-mediated and cell-selective gene transfer with polyethyleneimine (PEI)-based vector, we synthesized three galactosylated PEIs (Gal-PEI) with different molecular weights (PEI 1800 , PEI 10,000 , and PEI 70,000 ) and investigated their potential as a targetable vector to asialoglycoprotein...
We have examined the effects of the herbal medicine sho-saiko-to (SST) on nitric oxide (NO) biosynthesis in rat hepatocytes by measuring the stable end-product nitrite and the mRNA of inducible NO synthase (iNOS). Interferon-γ (IFN) by itself failed to induce NO synthesis (IFN: 1 - 1,000 u/ml). SST also did not elicit NO synthesis at concentrations up to 300 μg/ml when administered alone, but dose-dependently...
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