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Reversed Mitochondrial Dysfunction
Fullerenol nanoparticles are both stable and effective in protecting the degenerating retina. In article number 2205998, Yu Gong, Zhanjun Gu, Haiwei Xu, and co‐workers propose the potential utility of fullerenols for safeguarding the mitochondrial genome to maintain electron transport chain function and simultaneously reversing the abnormal nuclear DNA expression...
Poor therapeutic outcomes of antioxidants in ophthalmologic clinical applications, including glutathione during photoreceptor degeneration in retinitis pigmentosa (RP), are caused by limited anti‐oxidative capacity. In this study, fullerenols are synthesized and proven to be highly efficient in vitro radical scavengers. Fullerenol‐based intravitreal injections significantly improve the flash electroretinogram...
Bone repair in real time is a challenging medical issue for elderly patients; this is mainly because aged bone marrow mesenchymal stem cells (BMSCs) possess limited osteogenesis potential and repair capacity. In this study, triboelectric stimulation technology is used to achieve bone repair via mechanosensation of Piezo1 by fabricating a wearable pulsed triboelectric nanogenerator (WP‐TENG) driven...
Wearable Pulsed Triboelectric Nanogenerators
In article number 2201056, Zhen Wen, Cao Yang, Yue Pan, and co‐workers fabricate a wearable pulsed triboelectric nanogenerator driven by human body movement, the triboelectric stimulation of which could reinforce osteogenesis of bone marrow mesenchymal stem cells (BMSCs) and promote angiogenesis of human umbilical vein endothelial cells by rejuvenating...
Osteomyelitis is considered as the most serious bone infection, which can lead to the bone destruction or fatal sepsis. Clinical treatments through frequent antibiotics administration and surgical debridement bring inevitable side effects including drug‐resistance and disfigurements. It is urgent to develop an antibiotics‐free and rapid strategy to treat osteomyelitis. Herein, a bifunctional sonosensitizer...
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