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SIRT1 belongs to the sirtuin family of NAD + -dependent histone/protein deacetylases. Experimentally, increased activity of SIRT1 facilitates calorie-restricted longevity, and decreases NF-κB activation and the amount of the amyloid-β (Aβ). We studied SIRT1 in an aging-associated muscle disease, sporadic inclusion-body myositis (s-IBM), whose muscle fibers contain increased NF-κB activation...
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