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Fragmentation of E gene of JEV into smaller fragments, none of the fragments either in plasmids form or in recombinant protein form can induce optimal protection against the virus infection. It is only when DNA priming–protein boosting strategies are used then the N-terminal E A and the C-terminal E B showed full protection against JEV as those induced by commercial vaccine, provided...
The envelope (E) gene of Japanese encephalitis virus (JEV) plays a major protective role against JEV infection. In order to locate the part of E gene that is responsible for this protection, an N-terminal fragment E A (nucleotide number 933–1877bp of JEV genome) and a C-terminal fragment E B (nucleotide number 1851–2330bp of JEV genome) from E gene were prepared. Both of these fragments...
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