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Particle-induced carcinogenicity is not well understood, but might involve inflammation. The proinflammatory cytokine tumor necrosis factor (TNF) is considered to be an important mediator in inflammation. We investigated its role in particle-induced inflammation and DNA damage in mice with and without TNF signaling. TNF−/− mice and TNF+/+ mice were exposed by inhalation to 20 mg m−3 carbon black (CB),...
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