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Adaptation to intermittent high altitude (IHA) hypoxia can protect the heart against ischemia-reperfusion injury. In view of the fact that both Ca 2+ paradox and ischemia-reperfusion injury are associated with the intracellular Ca 2+ overload, we tested the hypothesis that IHA hypoxia may protect hearts against Ca 2+ paradox-induced lethal injury if its cardioprotection bases...
Endothelin (ET) isopeptides, ET-1, ET-2 and ET-3, elicit a positive inotropic effect (PIE) in association with a negative lusitropic effect, essentially with identical efficacies and potencies in the isolated rabbit papillary muscle, but with different concentration-dependent properties. Pharmacological analysis indicates that the PIE of ET-1 is mediated by an ET A2 subtype that is less...
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