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Deoxynucleotide sequencing of a cDNA for the dihydrolipoamide acetyltransferase (PDC-E 2 ) component of human pyruvate dehydrogenase complex (PDC) revealed an open reading frame of 1848 base pairs corresponding to a leader sequence of 54 amino acids and a mature protein of 561 amino acids (59 551 Da). Both an amino-terminal lipoyl-bearing domain and a carboxy-terminal catalytic domain are...
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