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As a key intermediate in a number of different metabolic pathways, acetyl-CoA is independently produced and consumed in the plastids, mitochondria, peroxisomes and cytosol. Recent studies have led to new understanding of the enzymes that generate these different acetyl-CoA pools, including the role of ATP-citrate lyase in producing acetyl-CoA in the cytosol and of the pyruvate dehydrogenase complex...
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