Search results for: A. GLYNN

Items from 1 to 20 out of 64 results

article

Proceedings of the 2022 NHLBI and OASH state of the science in transfusion medicine symposium

Brian Custer, Evan M. Bloch, Barbara J. Bryant, Angelo D'Alessandro, more

Background State of the Science (SoS) meetings are used to define and highlight important unanswered scientific questions. The National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, and the Office of the Assistant Secretary for Health (OASH), Department of Health and Human Services held a virtual SoS in transfusion medicine (TM) symposium. Study Design and Methods In...

article

Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency

Donald J. Brambilla, Michael P. Busch, Simone A. Glynn, Steven H. Kleinman, more

Transfusion > 61 > 2 > 494 - 502

Background The standard approach to estimating HIV incidence in repeat blood donors includes only donors who made two or more donations in an estimation interval. In China and some other countries, large proportions of repeat donors donate only once in a 1‐ or 2‐year interval. The standard approach may not represent risk among all repeat donors in these areas. Two approaches to including all repeat...

article

Recently acquired infection among HIV‐seropositive donors in the US from 2010‐2018

Claire Quiner, Roberta Bruhn, Eduard Grebe, Clara Di Germanio, more

Transfusion > 60 > 10 > 2340 - 2347

Background Monitoring of transfusion‐transmissible infections in the blood supply is essential for blood safety, as the donor population is not static, and changes in policy, donor behavior, or other factors could increase the risk of recipient infection. We assessed patterns of recently acquired HIV infection in US blood donors, including before and after the implementation of the 12‐month deferral...

article

Consequences of Health Insurance Cost Sharing Among Low‐Income Medicare Beneficiaries: Evidence from Benefit Cliffs in Medicaid and Medicare’s Prescription Drug Subsidy Program

E. Roberts, A. Glynn, J. Donohue, J. Michael McWilliams, more

Health Services Research > 55 > S1 > 98 - 99

Research Objective Cost sharing is intended to mitigate the effects of moral hazard in health insurance but can have unintended consequences if patients underuse medically beneficial care that is subject to out‐of‐pocket costs. The Medicare program requires substantial cost sharing, including deductibles and coinsurance for outpatient care and prescription drugs. However, little is known about the...

article

Methodological considerations for linked blood donor‐component‐recipient analyses in transfusion medicine research

Nareg H. Roubinian, Steven Kleinman, Edward L. Murphy, Simone A. Glynn, more

ISBT Science Series > 15 > 1 > 185 - 193

In recent years, there has been a concerted effort to improve our understanding of the quality and effectiveness of transfused blood components. The expanding use of large datasets built from electronic health records allows the investigation of potential benefits or adverse outcomes associated with transfusion therapy. Together with information regarding blood donor demographics and component collection...

article

Cardiovascular and cancer mortality in relation to dietary polychlorinated biphenyls and marine polyunsaturated fatty acids: a nutritional‐toxicological aspect of fish consumption

C. Donat‐Vargas, A. Bellavia, M. Berglund, A. Glynn, more

Journal of Internal Medicine > 287 > 2 > 197 - 209

Background Co‐exposure to environmental contaminants present in fish could mitigate the beneficial effects of fish consumption and possibly explain the lack of association observed for mortality in some geographical regions. Objective To assess the independent associations of dietary exposure to polychlorinated biphenyls (PCBs) and long‐chain omega‐3 fish fatty acids intake with cardiovascular...

article

Association of donor age, body mass index, hemoglobin, and smoking status with in‐hospital mortality and length of stay among red blood cell–transfused recipients

Nareg H. Roubinian, Matt Westlake, Elizabeth M. St. Lezin, Gustaf Edgren, more

Transfusion > 59 > 11 > 3362 - 3370

BACKGROUND Recent publications have reported conflicting findings regarding associations of blood donor demographics and mortality of transfused patients. We hypothesized that the analysis of additional donor characteristics and consideration of alternative outcomes might provide insight into these disparate results. STUDY DESIGN AND METHODS We analyzed data from a retrospective cohort of transfused...

article

Iron status and risk factors for iron depletion in a racially/ethnically diverse blood donor population

Bryan R. Spencer, Yuelong Guo, Ritchard G. Cable, Joseph E. Kiss, more

Transfusion > 59 > 10 > 3146 - 3156

BACKGROUND The optimal approach for reducing iron depletion (ID) in blood donors may vary depending on biologic or behavioral differences across donors. STUDY DESIGN AND METHODS More than 12,600 successful whole blood donors were enrolled from four US blood centers for ferritin testing. The study population was enriched for racial/ethnic minorities (1605 African American, 1616 Asian, 1023 Hispanic)...

article

Elevated risk for iron depletion in high‐school age blood donors

Bryan R. Spencer, Walter Bialkowski, Darryl V. Creel, Ritchard G. Cable, more

Transfusion > 59 > 5 > 1706 - 1716

BACKGROUND High school students 16 to 18 years‐old contribute 10% of the US blood supply. Mitigating iron depletion in these donors is important because they continue to undergo physical and neurocognitive development. STUDY DESIGN AND METHODS Study objectives were to determine the prevalence of iron depletion in 16‐ to 18‐year‐old donors and whether their risk for iron depletion was greater than...

article

Outcome for triple negative breast cancer in a retrospective cohort with an emphasis on response to platinum-based neoadjuvant therapy

Elaine M. Walsh, Aliaa Shalaby, Mark O’Loughlin, Nessa Keane, more

Breast Cancer Research and Treatment > 2019 > 174 > 1 > 1-13

Purpose The rate of pathological complete response (pCR) for patients with triple negative breast cancer (TNBC) is increased when carboplatin is added to neo-adjuvant chemotherapy (NACT). However, while phase III trial data showing a survival benefit are awaited, carboplatin is not yet standard-of-care for TNBC. The aim of this study was to examine the rate of pCR and the outcome for those treated...

article

Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer: a multi-institutional study

Mark O’Loughlin, Xavier Andreu, Simonetta Bianchi, Ewa Chemielik, more

Breast Cancer Research and Treatment > 2018 > 171 > 1 > 1-9

Background Several studies have demonstrated a prognostic role for stromal tumour infiltrating lymphocytes (sTILs) in triple-negative breast cancer (TNBC). The reproducibility of scoring sTILs is variable with potentially excellent concordance being achievable using a software tool. We examined agreement between breast pathologists across Europe scoring sTILs on H&E-stained sections without software,...

article

Addressing gaps in international blood availability and transfusion safety in low‐ and middle‐income countries: a NHLBI workshop

Brian Custer, Shimian Zou, Simone A. Glynn, Julie Makani, more

Transfusion > 58 > 5 > 1307 - 1317

In April 2017, a workshop sponsored by the National Heart, Lung, and Blood Institute, Division of Blood Diseases and Resources, and the Center for Translation Research and Implementation Science was held to discuss blood availability and transfusion safety in low‐ and middle‐income countries (LMICs). The purpose of the workshop was to identify research opportunities for implementation science (IS)...

article

Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro‐tumourigenic ‘activated’ state that enhances prostate cancer cell migration

Sarah M. Ridge, Dibyangana Bhattacharyya, Eoin Dervan, Serika D. Naicker, more

International Journal of Cancer > 142 > 10 > 2056 - 2067

Mesenchymal stem cells (MSCs) are a heterogeneous population of multipotent cells that are capable of differentiating into osteocytes, chondrocytes and adipocytes. Recently, MSCs have been found to home to the tumour site and engraft in the tumour stroma. However, it is not yet known whether they have a tumour promoting or suppressive function. We investigated the interaction between prostate cancer...

article

Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016

Jaroslav G. Vostal, Paul W. Buehler, Monique P. Gelderman, Abdu I. Alayash, more

Transfusion > 58 > 1 > 255 - 266

The US Food and Drug Administration (FDA) held a workshop on red blood cell (RBC) product regulatory science on October 6 and 7, 2016, at the Natcher Conference Center on the National Institutes of Health (NIH) Campus in Bethesda, Maryland. The workshop was supported by the National Heart, Lung, and Blood Institute, NIH; the Department of Defense; the Office of the Assistant Secretary for Health,...

article

A comparison of methods for estimating the incidence of human immunodeficiency virus infection in repeat blood donors

Donald J. Brambilla, Michael P. Busch, Roger Y. Dodd, Simone A. Glynn, more

Transfusion > 57 > 3pt2 > 823 - 831

BACKGROUND The incidence of human immunodeficiency virus (HIV) in repeat blood donors has been estimated using seven methods. Although incidence is always calculated as cases per person‐time, approaches to selecting cases and calculating person‐time vary. Incidence estimates have not been compared among methods. STUDY DESIGN AND METHODS The seven methods were compared in a simulation study. Because...

article

Mesenchymal stem cells: key players in cancer progression

Sarah M. Ridge, Francis J. Sullivan, Sharon A. Glynn

Molecular Cancer > 2017 > 16 > 1 > 1-10

Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells, fibroblasts, cells of the immune system and mesenchymal stem cells (MSCs). MSCs are multipotent stromal cells that are known to reside in various areas such as the bone marrow, fat and dental...

article

MON-P088: Establishing a Reactive Homeng Service Using Cortrak Enteral Access System (EAS) for Head and Neck Cancer Patients Undergoing Radiotherapy and/or Chemotherapy

Y. Donnelly, S. Brennan, F. Gilbert, A. Gorham, more

Clinical Nutrition > 2016 > 35 > S1 > S185

article

Recent viral infection in US blood donors and health-related quality of life (HRQOL)

Farnaz Vahidnia, Susan L. Stramer, Debra Kessler, Beth Shaz, more

Quality of Life Research > 2017 > 26 > 2 > 349-357

Purpose Blood donors are considered to be one of the healthiest populations, but relatively little is known about their perceived quality of life. The objective was to examine HRQOL in donors infected with HIV, HBV, HCV or HTLV and a comparison group. Methods Donors with confirmed viral infection (cases) and donors who tested false-positive (controls) participated in a multicenter study of US blood...

article

Effect of iron supplementation on iron stores and total body iron after whole blood donation

Ritchard G. Cable, Donald Brambilla, Simone A. Glynn, Steven Kleinman, more

Transfusion > 56 > 8 > 2005 - 2012

BACKGROUND Understanding the effect of blood donation and iron supplementation on iron balance will inform strategies to manage donor iron status. STUDY DESIGN AND METHODS A total of 215 donors were randomized to receive ferrous gluconate daily (37.5 mg iron) or no iron for 24 weeks after blood donation. Iron stores were assessed using ferritin and soluble transferrin receptor. Hemoglobin (Hb)...

article

Motivations for donating and attitudes toward screening policies in US blood donors with viral infection

Farnaz Vahidnia, Susan L. Stramer, Debra Kessler, Thelma T. Gonçalez, more

Transfusion > 56 > 8 > 2013 - 2020

BACKGROUND Differences in motivating factors that contribute to the decision to donate blood between infected and uninfected donors may help to identify areas for improving donor education. STUDY DESIGN AND METHODS As part of a risk factor study, confirmed‐positive donors (cases) based on serology‐only (human T‐lymphotropic virus [HTLV]) or serology and nucleic acid testing (NAT) or NAT‐only (human...

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INFONA - science communication portal

Search results for: A. GLYNN

Proceedings of the 2022 NHLBI and OASH state of the science in transfusion medicine symposium

Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency

Recently acquired infection among HIV‐seropositive donors in the US from 2010‐2018

Consequences of Health Insurance Cost Sharing Among Low‐Income Medicare Beneficiaries: Evidence from Benefit Cliffs in Medicaid and Medicare’s Prescription Drug Subsidy Program

Methodological considerations for linked blood donor‐component‐recipient analyses in transfusion medicine research

Cardiovascular and cancer mortality in relation to dietary polychlorinated biphenyls and marine polyunsaturated fatty acids: a nutritional‐toxicological aspect of fish consumption

Association of donor age, body mass index, hemoglobin, and smoking status with in‐hospital mortality and length of stay among red blood cell–transfused recipients

Iron status and risk factors for iron depletion in a racially/ethnically diverse blood donor population

Elevated risk for iron depletion in high‐school age blood donors

Outcome for triple negative breast cancer in a retrospective cohort with an emphasis on response to platinum-based neoadjuvant therapy

Reproducibility and predictive value of scoring stromal tumour infiltrating lymphocytes in triple-negative breast cancer: a multi-institutional study

Addressing gaps in international blood availability and transfusion safety in low‐ and middle‐income countries: a NHLBI workshop

Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro‐tumourigenic ‘activated’ state that enhances prostate cancer cell migration

Proceedings of the Food and Drug Administration's public workshop on new red blood cell product regulatory science 2016

A comparison of methods for estimating the incidence of human immunodeficiency virus infection in repeat blood donors

Mesenchymal stem cells: key players in cancer progression

MON-P088: Establishing a Reactive Homeng Service Using Cortrak Enteral Access System (EAS) for Head and Neck Cancer Patients Undergoing Radiotherapy and/or Chemotherapy

Recent viral infection in US blood donors and health-related quality of life (HRQOL)

Effect of iron supplementation on iron stores and total body iron after whole blood donation

Motivations for donating and attitudes toward screening policies in US blood donors with viral infection

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