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Background: Progressive left ventricular (LV) dilation after myocardial infarction (MI) and high norepinephrine in LV dysfunction carry an adverse prognosis. Our hypothesis was that prevention of repetitive rise of filling pressure and of plasma hormones during ordinary daily exercise may be important for prevention of further remodeling after infarction.Methods: 25 patients with progressive remodeling...
Although ACE inhibitors may reduce mortality in subacute myocardial infarction (MI), they could be harmful during intense neurohumoral activation in acute MI. We investigated the contribution of angiotensin-II (AII) synthesis inhibition, bradykinin (BK) breakdown, and dosage to the effects of ACE inhibitors. Three hours after coronary ligation or sham operation, rats received the AT 1 -receptorblocker...
Background: The mechanism of reduced mortality after infarction (MI) by betablocker is not fully understood. It could be a specific betablocker effect, an effect related to heart rate (HR) reduction of the prevention of left ventricular (LV) remodelling or a combined effects. We examined, therefore, the effects of zatebradine (Z), a specific bradycardic agent, to LV function, diastolic wall stress,...
Background: Although infarct (MI) size is the most important determinant for the left ventricular (LV) dilation and remodeling, individual variability of LV volume to a givem MI size is high in patients. We analyzed this nonuniform relationship between MI size and degree of LV dilatation and potential hemodynamic consequences in rat with chronic MI.Methods: Eight weeks post MI or sham operation,...
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