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Cocaine addiction is characterized by a progressive increase in drug intake and a persistent craving for the drug during prolonged abstinence. Whether these two prominent features of cocaine addiction are related to each other and are mediated by similar or different neuronal processes is currently unknown.Rats were first allowed to self-administer cocaine under long-access (6-hour) conditions to...
Rationale and objectives. Prolonged access to cocaine self-administration (long access or LgA) produces an escalation in drug intake not observed with limited access to the drug (short access or ShA). The present study tested the hypothesis that escalating use of cocaine is associated with chronic alterations in dopamine neurotransmission. Methods. After escalation of cocaine self-administration,...
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