Search results for: Eduardo Arilla

Items from 1 to 20 out of 22 results

article

Ellagic acid protects from myelin-associated sphingolipid loss in experimental autoimmune encephalomyelitis

Rebeca Busto, Jorge Serna, Aránzazu Perianes-Cachero, Rocío Quintana-Portillo, more

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids > 2018 > 1863 > 9 > 958-967

Experimental autoimmune encephalomyelitis (EAE), the most common model for multiple sclerosis, is characterized by inflammatory cell infiltration into the central nervous system and demyelination. Previous studies have demonstrated that administration of some polyphenols may reduce the neurological alterations of EAE. In this work, we show that ellagic acid, a polyphenolic compound, is beneficial...

article

Improvement in glycemia after glucose or insulin overload in leptin-infused rats is associated with insulin-related activation of hepatic glucose metabolism

Emma Burgos-Ramos, Sandra Canelles, Laura M. Frago, Julie A. Chowen, more

Nutrition & Metabolism > 2016 > 13 > 1 > 1-6

Background Insulin regulates glucose homeostasis through direct effects on the liver, among other organs, with leptin modulating insulin’s hepatic actions. Since central leptin may modify insulin signaling in the liver, we hypothesized that leptin infusion activates hepatic glycogen synthesis following peripheral administration of a bolus of glucose or insulin, thus regulating glycemia. Findings...

article

Reduction in Aβ‐induced cell death in the hippocampus of 17β‐estradiol‐treated female rats is associated with an increase in IGF‐I signaling and somatostatinergic tone

Aránzazu Perianes‐Cachero, Sandra Canelles, David Aguado‐Llera, Laura M. Frago, more

Journal of Neurochemistry > 135 > 6 > 1257 - 1271

Several studies indicate that 17β‐estradiol (E2) protects against amyloid β‐peptide (Aβ)‐induced cell death and activates factors associated with learning and memory, a function involving the hippocampal somatostatinergic system. As alterations in somatostatin have been demonstrated in Alzheimer′s disease, we examined whether E2 prevents changes in the hippocampal somatostatinergic system induced...

article

Vitamin E deficiency impairs the somatostatinergic receptor–effector system and leads to phosphotyrosine phosphatase overactivation and cell death in the rat hippocampus

Alberto M. Hernández-Pinto, Lilian Puebla-Jiménez, Aránzazu Perianes-Cachero, Eduardo Arilla-Ferreiro

The Journal of Nutritional Biochemistry > 2013 > 24 > 5 > 848-858

Vitamin E plays an essential role in maintaining the structure and function of the nervous system, and its deficiency, commonly associated with fat malabsorption diseases, may reduce neuronal survival. We previously demonstrated that the somatostatinergic system, implicated in neuronal survival control, can be modulated by α-tocopherol in the rat dentate gyrus, increasing cyclic adenosine monophosphate...

article

Leptin-induced downregulation of the rat hippocampal somatostatinergic system may potentiate its anorexigenic effects

Arancha Perianes-Cachero, Emma Burgos-Ramos, Lilian Puebla-Jiménez, Sandra Canelles, more

Neurochemistry International > 2012 > 61 > 8 > 1385-1396

The learning and memory mechanisms in the hippocampus translate hormonal signals of energy balance into behavioral outcomes involved in the regulation of food intake. As leptin and its receptors are expressed in the hippocampus and somatostatin (SRIF), an orexigenic neuropeptide, may inhibit leptin-mediated suppression of food intake in other brain areas, we asked whether chronic leptin infusion induces...

article

Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3

Emma Burgos‐Ramos, Julie A. Chowen, Eduardo Arilla‐Ferreiro, Sandra Canelles, more

Journal of Neurochemistry > 117 > 1 > 175 - 185

J. Neurochem. (2011) 117, 175–185. AbstractLeptin and insulin have overlapping intracellular signaling mechanisms and exert anorexigenic actions in the hypothalamus. We aimed to determine how chronic exposure to increased leptin affects the hypothalamic response to a rise in insulin. We analyzed the activation and interactions of components of the phosphatidylinositol 3‐kinase (PI3K)/Akt pathway...

article

17β-Estradiol protects depletion of rat temporal cortex somatostatinergic system by β-amyloid

David Aguado-Llera, Eduardo Arilla-Ferreiro, Julie A. Chowen, Jesús Argente, more

Neurobiology of Aging > 2007 > 28 > 9 > 1396-1409

Estradiol prevents amyloid-beta peptide (Aβ)-induced cell death through estrogen receptors (ERs) and modulates somatostatin (SRIF) responsiveness in the rat brain. As intracerebroventricular (ICV) Aβ25-35 administration reduces SRIFergic tone in the temporal cortex of ovariectomized (Ovx) rats, we asked whether 17β-estradiol (E2) treatment can restore the Aβ25-35 induced changes in SRIF content, SRIF...

article

Differential effects of ethanol ingestion on somatostatin content, somatostatin receptors and adenylyl cyclase activity in the frontoparietal cortex of virgin and parturient rats

Vicente Barrios, Lilian Puebla-Jiménez, María del Carmen Boyano-Adánez, Manuel Sanz, more

Life Sciences > 2005 > 77 > 10 > 1094-1105

Chronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparietal cortex of virgin and parturient rats given ethanol in their drinking water before and during gestation...

article

Activity of the hippocampal somatostatinergic system following daily administration of melatonin

Rosa Marı́a Izquierdo-Claros, Marı́a del Carmen Boyano-Adánez, Eduardo Arilla-Ferreiro

Molecular Brain Research > 2004 > 126 > 2 > 107-113

If melatonin or its analogs are to be used therapeutically in humans, their chronic effects on responsiveness of melatonin target cells need to be assessed. We have previously demonstrated that acute melatonin treatment regulates the somatostatinergic system in the rat hippocampus. In the present study, we have investigated the effects of subchronic and chronic daily treatment with melatonin on the...

article

Influence of fluoxetine and p-chloroamphetamine on the somatostatin receptor–adenylyl cyclase system in the rat frontoparietal cortex

Gema Muñoz-Acedo, Rosa Marı́a Izquierdo-Claros, Lilian Puebla, Eulalia Rodrı́guez-Martı́n, more

Molecular Brain Research > 1997 > 47 > 1-2 > 117-124

There is evidence that suggests a reciprocal functional link between the serotonergic and the somatostatinergic system in the rat frontoparietal cortex. However, to date, the role of endogenous 5-hydroxytryptamine (serotonin) on the regulation of the somatostatin (SS) receptor–adenylyl cyclase (AC) system remains unclear. In the present study, the administration of fluoxetine (10 mg/kg i.p.), a 5-hydroxytryptamine...

article

Acute effects of D1- and D2-receptor agonist and antagonist drugs on somatostatin binding, inhibition of adenylyl cyclase activity and accumulation of inositol 1,4,5-trisphosphate in the rat striatum

Rosa Marı́a Izquierdo-Claros, Marı́a del Carmen Boyano-Adánez, Christer Larsson, Lena Gustavsson, more

Molecular Brain Research > 1997 > 47 > 1-2 > 99-107

A recent study carried out by our group demonstrated that exogenous dopamine increases the somatostatin (SS) receptor–effector system in the rat striatum. The present study examined the participation of the D ₁ - and D ₂ -dopaminergic systems in the modulation of the rat striatal SS receptor–effector system by use of the D ₁ -receptor agonist and antagonist SKF 38393 and SCH...

article

Histamine H ₁ -Receptors Modulate Somatostatin Receptors Coupled to the Inhibition of Adenylyl Cyclase in the Rat Frontoparietal Cortex

Lilian Puebla, Aurelio Ocaña Fuentes, Eduardo Arilla

Peptides > 1997 > 18 > 10 > 1569-1576

Since exogenous histamine has been previously shown to increase the somatostatin (SS) receptor-effector system in the rat frontoparietal cortex and both histamine H ₁ -receptor agonists and SS modulate higher nervous activity and have anticonvulsive properties, it was of interest to determine the participation of the H ₁ -histaminergic system in this response. The intracerebroventricular...

article

Effect of Dimaprit and Cimetidine on the Somatostatinergic System in the Rat Frontoparietal Cortex

Lilian Puebla, Eduardo Arilla

Neuropsychopharmacology > 1996 > 14 > 5 > 367-374

A recent study carried out by this laboratory demonstrated that exogenous histamine increases the somatostatin (SS) receptor/effector system in the rat frontoparietal cortex (Puebla and Arilla, 1995). In the present study we examined the participation of the H ₂ -histaminergic system in this modulation by use of the H ₂ -receptor agonist and antagonist dimaprit and cimetidine, respectively...

article

Modulation by 5-hydroxytryptamine of the somatostatin receptor-effector system and somatostatin levels in rat brain

Gema Muñoz-Acedo, Eduardo Arilla

Molecular Brain Research > 1996 > 37 > 1-2 > 259-266

The role of 5-hydroxytryptamine (5-HT) in the acute regulation of the rat brain somatostatin (SS) receptor-effector system and somatostatin-like immunoreactivity (SSLI) content was examined. 5-HT administered i.c.v. in a volume of 10 μl at a dose of 0.5 μg (pH 3.4) increased the SSLI concentration at 60 min in the Wistar rat frontoparietal cortex and hippocampus (60%, P < 0.05; 72%, P < 0.01;...

article

Hippocampal somatostatin receptors and modulation of adenylyl cyclase activity in histamine-treated rats

Lilian Puebla, Eulalia Rodríguez-Martín, Eduardo Arilla

Molecular Brain Research > 1996 > 35 > 1-2 > 77-83

In the present study, the effects of an intracerebroventricular (i.c.v.) dose of histamine (0.1, 1.0 or 10.0 μg) on the hippocampal somatostatin (SS) receptor/effector system in Wistar rats were investigated. In view of the rapid onset of histamine action, the effects of histamine on the somatostatinergic system were studied 2 h after its administration. Hippocampal SS-like immunoreactivity (SSLI)...

article

α-Fluoromethylhistidine influences somatostatin content, binding and inhibition of adenylyl cyclase activity in the rat frontoparietal cortex

Lilian Puebla, Eduardo Arilla

Regulatory Peptides > 1995 > 59 > 1 > 111-120

Slow-wave sleep, wakefulness, locomotor activity and learning and memory are regulated in similar ways by somatostatin (SS) and histamine. To clarify the possible role of endogenous histamine on the somatostatinergic system of the rat frontoparietal cortex, we studied the effect of 50 μg of α-fluoromethylhistidine (α-FMH), a specific inhibitor of histidine decar☐ylase, administered intracerebroventricularly...

article

The benzodiazepine antagonist CGS 8216 prevents hyperammonemia-induced somatostatin receptor reduction in the brain

María del Carmen Boyano-Adánez, Guillermo Bodega, Ángela Martín-Espinosa, Eduardo Arilla

Brain Research > 1995 > 688 > 1-2 > 1-7

Previous results from our group showed that hyperammonemia decreases the number of somatostatin (SS) receptors and that benzodiazepine receptors might regulate the number of SS receptors in rat brain. These findings together with the supersensitivity of benzodiazepine receptors in the hyperammonemic rat brain suggest that benzodiazepine receptors might mediate the effect of hyperammonemia on SS receptors...

article

Ethanol-induced modification of somatostatin-responsive adenylyl cyclase in rat exocrine pancreas

Itziar Alvaro-Alonso, María del Carmen Boyano-Adánez, Eduardo Arilla

BBA - Molecular Cell Research > 1995 > 1268 > 1 > 115-121

Male rats were given 10% (w/v) ethanol in drinking fluid during the first week, 15% (w/v) during the second week, 20% (w/v) during the third, and 25% (w/v) during the fourth week, at the end of which they were kept on 25% (w/v) ethanol drinking water for 3 weeks. Some animals were then allowed the withdrawal of ethanol for a period of 2 weeks or 7 weeks. No significant differences were seen for...

article

Exogenous histamine increases the somatostatin receptor/effector system in the rat frontoparietal cortex

Lilian Puebla, Eduardo Arilla

European Journal of Pharmacology: Molecular Pharmacology > 1995 > 289 > 2 > 361-368

The present study examined the effects of histamine on somatostatin-like immunoreactivity levels, binding of ¹ ² ⁵ I-[Tyr ¹ ¹ ]somatostatin to its specific receptors, somatostatin inhibition of basal and forskolin-stimulated adenylyl cyclase activity and inhibitory guanine-nucleotide binding protein (G _i ) function in the rat frontoparietal cortex. An intracerebroventricular...

article

Exogenous histamine increases the somatostatin receptor/effector system in the rat frontoparietal cortex

Lilian Puebla, Eduardo Arilla

European Journal of Pharmacology > 1995 > 289 > 2 > 361-368

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Search results for: Eduardo Arilla

Ellagic acid protects from myelin-associated sphingolipid loss in experimental autoimmune encephalomyelitis

Improvement in glycemia after glucose or insulin overload in leptin-infused rats is associated with insulin-related activation of hepatic glucose metabolism

Reduction in Aβ‐induced cell death in the hippocampus of 17β‐estradiol‐treated female rats is associated with an increase in IGF‐I signaling and somatostatinergic tone

Vitamin E deficiency impairs the somatostatinergic receptor–effector system and leads to phosphotyrosine phosphatase overactivation and cell death in the rat hippocampus

Leptin-induced downregulation of the rat hippocampal somatostatinergic system may potentiate its anorexigenic effects

Chronic central leptin infusion modifies the response to acute central insulin injection by reducing the interaction of the insulin receptor with IRS2 and increasing its association with SOCS3

17β-Estradiol protects depletion of rat temporal cortex somatostatinergic system by β-amyloid

Differential effects of ethanol ingestion on somatostatin content, somatostatin receptors and adenylyl cyclase activity in the frontoparietal cortex of virgin and parturient rats

Activity of the hippocampal somatostatinergic system following daily administration of melatonin

Influence of fluoxetine and p-chloroamphetamine on the somatostatin receptor–adenylyl cyclase system in the rat frontoparietal cortex

Acute effects of D1- and D2-receptor agonist and antagonist drugs on somatostatin binding, inhibition of adenylyl cyclase activity and accumulation of inositol 1,4,5-trisphosphate in the rat striatum

Histamine H ₁ -Receptors Modulate Somatostatin Receptors Coupled to the Inhibition of Adenylyl Cyclase in the Rat Frontoparietal Cortex

Effect of Dimaprit and Cimetidine on the Somatostatinergic System in the Rat Frontoparietal Cortex

Modulation by 5-hydroxytryptamine of the somatostatin receptor-effector system and somatostatin levels in rat brain

Hippocampal somatostatin receptors and modulation of adenylyl cyclase activity in histamine-treated rats

α-Fluoromethylhistidine influences somatostatin content, binding and inhibition of adenylyl cyclase activity in the rat frontoparietal cortex

The benzodiazepine antagonist CGS 8216 prevents hyperammonemia-induced somatostatin receptor reduction in the brain

Ethanol-induced modification of somatostatin-responsive adenylyl cyclase in rat exocrine pancreas

Exogenous histamine increases the somatostatin receptor/effector system in the rat frontoparietal cortex

Exogenous histamine increases the somatostatin receptor/effector system in the rat frontoparietal cortex

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