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We investigated whether morphine and its pro-drug codeine are substrates of the highly genetically polymorphic organic cation transporter OCT1 and whether OCT1 polymorphisms may affect morphine and codeine pharmacokinetics in humans.Morphine showed low transporter-independent membrane permeability (0.5×10 −6 cm/s). Morphine uptake was increased up to 4-fold in HEK293 cells overexpressing human...
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