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Six sesquiterpenoids, namely jinkoh-eremol, agarospirol, α- and β-santalols, dehydrocostus lactone and costunolide, isolated from oriental incenses inhibited acetic acid-induced writhing in mice. The incidence of writhing produced by jinkoh-eremol, α-santalol and costunolide were revealed by administration of naloxone (μ-, κ- and δ-antagonists). Inhibitory activities of α-santalol on opioid receptors...
Saussurea root (Mokko in Japanese; root of Saussurea lappa, Compositae) is an aromatic stomachic and sedative in Oriental medicine. Four extracts of saussurea root were obtained by successively extracting with benzene, chloroform, methanol and water.Each of these extracts was tested for effects on the central nervous system (CNS) of mice by intraperitoneal administration, i. e. potentiation of hexobarbital...
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