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The study conveys an idea to enhance the osseointegration of titanium implant (Ti) through modulating macrophages M2 polarization. The ~ 100 nm spherical mesoporous silica nanoparticles (MSN) that compromised of ~ 4-nm-diameter nano-tunnels were synthesized by the conventional “sol–gel” method, into which the dexamethasone (DEX) was loaded (DEX@MSN). The DEX@MSN could consistently release DEX and...
Excessive reactive oxygen species (ROS) play an important role in the development of osteoporosis. Ophiopogonin D (OP-D), isolated from the traditional Chinese herbal agent Radix Ophiopogon japonicus, is a potent anti-oxidative agent. We hypothesized that OP-D demonstrates anti-osteoporosis effects via decreasing ROS generation in mouse pre-osteoblast cell line MC3T3-E1 subclone 4 cells and a macrophage...
Estrogen plays an essential role in bone formation, and estrogen modulation dysfunction is tightly associated with postmenopausal osteoporosis (PMOP). The underlying mechanisms of estrogen-mediated osteogenic differentiation have not been well defined. In this study, murine bone marrow mesenchymal stem cells were induced to undergo osteogenic differentiation, and gene expression analysis or GPR40...
Reactive oxygen species (ROS) are a significant pathogenic factor of osteoporosis. Ginsenoside-Rb 2 (Rb 2 ), a 20(S)-protopanaxadiol glycoside extracted from ginseng, is a potent antioxidant that generates interest regarding the bone metabolism area. We tested the potential anti-osteoporosis effects of Rb 2 and its underlying mechanism in this study. We produced an oxidative...
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